To understand why TRIM15 is upregulated after TKI treatment in HCC cells, we used the online KnockTF2.0 database (http://www.licpathway.net/KnockTF/search.php) to predict the potential transcription factors for TRIM15 (Fig. 2a) and use ChIP-Atlas database (http://chip-atlas.org/) to investigate whether these transcription factors bound to the promoter region of TRIM15. The KnockTF2.0 database showed a variety of transcriptional factors, such as SAFB2, FIP1L1, FUBP2, or FOXO1, could be the transcriptional factors for TRIM15. Here, TRIM15 is linked to hepatocellular carcinoma.