IL6 and neoplasm: Dysregulation of TME frequently causes systemic inflammation, which is called cancer‐cell‐intrinsic inflammation.[34] Abundant CXC chemokine (such as CXCL1, CXCL2 and CXCL8), growth factors (G‐CSF and GM‐CSF) and inflammatory cytokines (for example, IL‐6, IL‐1β, and IL‐17) produced by tumor cells, tumor‐associated stromal cells and tumor infiltrating leukocytes facilitate neutrophil infiltration.[19] TANs participate in multiple metastatic cascades.