Overall, our findings not only provide a novel mechanism of TANs associated LN metastasis of tumor cells via ETV4‐CXCL1/8‐CXCR2‐VEGFA/MMP9 pathway‐mediated lymphangiogenesis, but also point to potential targets for drug development against LN metastasis of BCa (Figure 7I). The gene discussed is VEGFA; the disease is neoplasm.