More than 60 variants in FLG leading to loss of filaggrin function have been identified in association with AD, with the most common among Europeans being c.1537C>T:R501X and 2282del4:S761Cfs*36 and, in sub-Saharan Africans, c.9947C>G:S3316*. This evidence concerns the gene FLG and Alzheimer disease.