In conclusion, we authors identified null variants of the FLG gene (in exon-3) (c.1537C>T:501X, c.2282del4:S761Cfs*36 and c.2512C>T:R826X) in 10% of Brazilian patients with AD, but without an association with the main clinical characteristics of AD. The gene discussed is FLG; the disease is Alzheimer disease.