Progression of encephalomyelitis in the spinal cord was accompanied by increased expression of NLRP3, whereas loss of NLRP3, Casp1, ASC, or IL-1β in mice led to resistance to encephalomyelitis (Furlan et al., 1999; Matsuki et al., 2006; Inoue et al., 2012). This evidence concerns the gene NLRP3 and encephalomyelitis.