In a rat model, inhibition of the NLRP3 inflammasome by INF39, an acrylate derivative and irreversible inhibitor of NLRP3, decreased IL-1β secretion and alleviated colitis induced by 2,4-dinitrobenzenesulfinic acid in rats (Cocco et al., 2017). The gene discussed is IL1B; the disease is colitis.