These include autoinflammatory diseases known as cryopyrin-associated periodic syndromes (CAPS) that are caused by hereditary gain-of-function mutations of the NLRP3 gene; infectious illnesses that display prominent inflammatory lesions; and chronic diseases that are marked by chronic inflammation elicited by sterile danger signals derived from metabolic abnormality, accumulation of crystals and aggregates, neurodegeneration, and oncogenic and metastatic processes (Mangan et al., 2018). The gene discussed is NLRP3; the disease is cryopyrin-associated periodic syndrome.