ATP5F1C and prion disease: We also observed significant enrichment in proteins associated with protein misfolding, including Parkinson's disease (KEGG ID: H00057), Prion disease (KEGG ID: H00061), and Amyotrophic lateral sclerosis (KEGG ID: H00058), within which we routinely observed mitochondrial ATP synthases Atp5f1b and Atp5f1c, among other proteins in the high hemin specificity class (Table S5).