Contrary to our finding, a more recent study showed that USP7 is a potent negative regulator of WNT/β-catenin signaling by deubiquitinating and stabilizing AXIN (Ji et al., 2019), casting doubt on the use of USP7 as WNT inhibitor for patients with APC-mutated CRC. Here, USP7 is linked to colorectal carcinoma.