In human, somatic and germline mutations of APC were discovered in patients with CRC in 1991 (Groden et al., 1991; Joslyn et al., 1991; Kinzler et al., 1991; Nishisho et al., 1991), where the majority of somatic APC mutations occur in the “mutation cluster region” (MCR) between codons 1286 and 1513 (Polakis, 1995; Vogelstein and Kinzler 2004). The gene discussed is APC; the disease is colorectal carcinoma.