We defined clinical precedence as a non-synonymous mutation of the residue in COSMIC,12 TCGA, ClinVar,54 literature on JAK1 mutations with known effect,1 and data from patients receiving ICB, where cancer exome sequencing data are publicly available,6,8,55,56,57,58,59,60 but absence from gnomADv3.161 (Table S3). The gene discussed is JAK1; the disease is cancer.