ASS1 and cancer: In MPM cell lines, the LC50 ranged from 9.7 μmol/L to >1.2 mmol/L (Supplementary Fig. S15B); however, mizoribine sensitivity appeared unrelated to ASS1 expression or BAP1 status, correlating most closely with proliferative capacity (Supplementary Fig. S15C) and suggesting MPM are biologically distinct from other ASS1-high cancers (45).