The tumor microenvironment (TME) consists of extracellular matrix components, especially collagen, fibronectin, hyaluronan, and laminin, as well as tumor cells, tumor stromal cells (including stromal fibroblasts), endothelial cells, and immune cells (microglia, macrophages, and lymphocytes) [169,170,171]. Here, FN1 is linked to neoplasm.