The M1-related cytokines, IFN-γ and TNF-α, increased and reached a peak at the 6th week post-infection (with IFN-γ higher than TNF-α), while the M2-related cytokines, IL-10 and IL-13, were boosted during the late stage of infection (with higher IL-10 than IL-13; Figure 1f,g). The gene discussed is TNF; the disease is infection.