The shift from M1 to M2 during the infection course was correlated with the secretion of Th1 cytokines (IFN-γ and TNF-α), changing to Th2 cytokines (IL-10 and IL-13), further indicating that M1 is related to the pro-inflammatory response and M2 to the Th2/regulatory response. The gene discussed is IL10; the disease is infection.