A subgroup analysis based on the study design revealed no difference in the SMD of the IL-10 levels between patients with severe and non-severe malaria in cross-sectional studies (p = 0.31, pooled SMD: 0.19, 95% CI: −0.1800.58, I2: 0%, 2 studies), prospective studies (p = 0.12, pooled SMD: 0.87, 95% CI: −0.21–1.94, I2: 98.31%, 11 studies/12 sub-studies), and retrospective studies (p = 0.05, SMD: 0.64, 95% CI: 0.01–1.33, I2: 89.26%, 6 studies/7 sub-studies, Figure 3). Here, IL10 is linked to malaria.