Overall, the meta-analysis results showed that patients with severe malaria had a higher SMD of the IL-10 levels than those with non-severe malaria (p = 0.03, pooled SMD: 0.74, 95% CI: 0.08–1.40, I2: 97.22%, 19 studies/21 sub-studies, Figure 2). This evidence concerns the gene IL10 and malaria.