The World Health Organization (WHO) revised dengue case classification, where severe dengue cases were reported to contain severe plasma leakage leading to dengue shock syndrome and fluid accumulation with respiratory distress, severe bleeding, and severe organ involvement, including the liver (AST or ALT ≥ 1000) and central nervous system, which may cause impaired consciousness, and other organs including heart, and occasional death may occur [29,30]. This evidence concerns the gene GPT and dengue disease.