In many laboratory mammalian animal models, TBT exposure was associated with reproductive, metabolic, and cardiovascular abnormalities, including hyperandrogenism, cystic ovarian follicles, irregular estrous cycle, elevated levels of LH, obesity, abnormal lipid profiles, glucose metabolism, and insulin resistance similar to those found in polycystic ovarian syndrome (PCOS) in women and animal models of PCOS [22,63,64,65]. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.