IFNG and tuberculosis: Analysis to explore the connection between IFN-γ producing capacity of T cells and disease severity as classified into three TB severity classes (SCI-III) using TB score showed a significantly lower frequency in SEB stimulated PBMCs of helminth positive PTB patients with SCII (p < 0.001) and SCIII (p < 0.001) compared to helminth positive PTB patients of the SCI group (Fig 6B).