Similarly, in TB patients we observed a significantly reduced frequency of IFN-γ+CD4+ T cells with S. mansoni and Ascaris showed a non-significant 2-fold reduction, whereas hookworm coinfection did not affect the frequency of IFN-γ+CD4+ T cells to the same extent, although these results should be interpreted with caution due to the few subjects included. This evidence concerns the gene IFNG and tuberculosis.