LTBI positive individuals (QFT+) with helminth infection showed a lower frequency of IFN-γ+CD4+ T cells in PPD (p< 0.05) and SEB (p< 0.05) stimulation (Fig 3A), as well as IFN-γ+CD4- T cells with a similar pattern (Fig 3C), when compared to helminth negative LTBI subjects. Here, CD4 is linked to helminthiasis.