This suppressed IFN-γ producing capacity of T cells might be related to the mechanism whereby helminth infections induce a Th-2 skewed immunity and increase in regulatory T cell responses for the establishment of long-standing infection in the host [29] which then greatly contribute to established infections by intracellular pathogens such as Mtb where a suppressed immune response enhances their risk for disease progression. This evidence concerns the gene IFNG and infection.