To obtain insights into the mechanism of resistance to CR-induced tumor suppression, genomic alterations involving relevant tumor suppressor genes (Cdkn2a, Ikzf1, Bcl11b, Pten) were analyzed in radiation-induced TLs that developed under non-CR (95 kcal) and CR (65 kcal) conditions by combining PCR-based LOH analysis and aCGH analysis. Here, PTEN is linked to neoplasm.