GNAS and migraine disorder: Based on the current systematic review and mete-analysis, acupuncture protects against migraine in rats was associated with elevated the 50%PTW value, decreased levels of Gsα, increased the level of Giα, and reduced Gsα/Giα protein ratio, thus regulating the signaling system inside and outside the cell membrane and the transcriptional expression of various target genes in the nucleus, leading to the improvement of the intracranial vasomotor function (Fig 6).