APOC3 and aortic stenosis: In severe aortic stenosis (AS), serum levels of apolipoproteins, including apolipoprotein C-III, B, A-I, and E, predicted hypofibrinolysis better than total cholesterol, LDL-C, or triglyceride levels.124 Of note, the association of decreased LDL-C with improvement in clot permeability and lysability supports the concept that LDL, likely via apolipoproteins, can affect the fibrin clot phenotype.