Recently, Kagamu et al. reported that the CD4+ T cell meta-cluster in peripheral blood just before PD-1 blockade therapy could predict the outcome of advanced NSCLC patients after its treatment, moreover, correlated with CD4+ T cell infiltration in the tumor microenvironment, moreover, peripheral Th1 correlated with CD8+ T cell infiltration [5]. The gene discussed is CD8A; the disease is non-small cell lung carcinoma.