Comparing the ionocytes expressing CFTR between the two groups, it was found that there was a significant decrease in the expression of CFTR in the CRS group (P < 0.01), which means the number of ionocytes in the CRS group was lower and the number of ionocytes that did not express CFTR was higher (Table S1, Fig. 2a). The gene discussed is CFTR; the disease is congenital rubella syndrome.