In the present study, we found that the expression of c-myc was significantly decreased in HCC cells after treatment of isolated and purified Halorotetin A. c-met is a hepatocyte growth factor with a tyrosine kinase activity [33], which is not only involved in cell signaling transduction and cytoskeletal arrangement but also related to the regulation of cell proliferation [34]. Here, HGF is linked to hepatocellular carcinoma.