ACHE and Alzheimer disease: A new tacrine derivative with acetylcholinesterase inhibition (AChE) and brain-derived neurotrophic factor (BDNF) activation was obtained by linking tacrine with a fragment of huperzine A, and it has been shown to have a cognitive enhancement effect in two kinds of AD mice (APP/PS1transgenic mice and β-amyloid (Aβ) oligomers-treated mice) without inducing significant hepatotoxicity [149].