The results demonstrated that fucosanthin may effectively reverse cognitive impairment by inhibiting oxidative stress and upregulating the expression of BDNF and ChAT in Aβ1-42 oligomeric-treated mice, suggesting that fucosanthin reduces Aβ neurotoxicity in vivo, which may be useful for prevention of AD [107]. The gene discussed is BDNF; the disease is Alzheimer disease.