PFKFB3 and cancer: Enzymes phosphatidylinositol 3-kinase (PI3K) and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFK-2/FBPase 3, PFKFB3), which played a significant role in the regulation of glycolysis in cancer cells as well as its proliferation and survival [21], were used for assessment of enzyme activities in our study.