Compounds from Psoraleae Fructus were able to detect neuroinflammation, oxidative damage and amyloid β-peptide 42(Aβ42), BACE1(β-secretase) activity, glycogen synthase kinase 3β, and AChE, which play a role in the basic mechanisms of AD, in vitro. This evidence concerns the gene BACE1 and Alzheimer disease.