Considering the known stimuli for the release of BNP, which encompass cardiovascular diseases such as severe AS, which leads to chronic hypertrophy of the left ventricle, the worth of the calculated cut-off value for BNP (1172.0 pg/mL, sensitivity = 0.51, specificity = 0.80) remains questionable [29]. This evidence concerns the gene NPPB and aortic valve stenosis.