CD28 and congestive heart failure: Data from the A systems BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT-CHF) study cohort have introduced some potential therapeutic targets, such as the blockage of inducible costimulator ligand (ICOSLG), TNF superfamily member-14 (TNFSF14), CD28, CD70 and the enhancement of interferon-γ production [130].