PD-L1 expression was shown to vary between nccRCC subtype in a series that demonstrated PD-L1 positivity of 5.6% in chromophobe RCC, 10% in papillary RCC, 20% in Xp11.2 translocation RCC and 20% in collecting duct carcinoma [52]. Here, CD274 is linked to renal cell adenocarcinoma.