NFE2L2 and esophageal squamous cell carcinoma: Nine of these genes (HSPA6, SP100A12, CACYBP, NOS2, DKK1, DSM, STC2, NGPTL3 and NRF2) defined two ESCC subgroups: a high-risk subgroup with the enrichment of M0 and M2 macrophages and activated mast cells and a low-risk subgroup rich in CD8 T cells and regulatory T cells [51].