NOTCH1 and cancer: An evaluation of the clonal status of somatic mutations showed that cancer-related genes found on the trunks, such as TP53, NOTCH1, KMT2D, and CREBBP, are predominantly mutated in a clonal manner; in contrast, other driver mutations, such as those occurring in MTOR, KEAP1, PTPRB and FAM135B, are subclonal.