Thus, Huang et al. reported the occurrence of c-MYC gene amplification in 43% of patients with ESCC; in patients with c-MYC amplification, the PFS and OS medians were 24 and 31 months, compared with 48 and 48 months, respectively, for patients without c-MYC amplification [40]. Here, MYC is linked to esophageal squamous cell carcinoma.