Large-scale chromosome deletions at 9p21.3 (CDKN2A) and 2q35 (ASCL3, FEV) and amplifications at 11q13.3 (CCND1), 5p15.33, 8q24 and 2q31.2 (NFE2L2) were common in both ESD and ESCC; however, ESCC contained more recurrent copy number alterations that ESDs [7]. This evidence concerns the gene NFE2L2 and esophageal squamous cell carcinoma.