The subclassification of the type of immune cells predominate in the tumor, as evaluated using gene expression profiling, showed that the CD8, CD4 and B cell classes have response rates to NAC of 73%, 74% and 75%, respectively, while the neutrophil class displayed a response rate of only 38%; however, compared with the neutrophil class, only the CD4 tumor class displayed a significantly prolonged overall survival rate [54]. This evidence concerns the gene CD8A and neoplasm.