CD4 and neoplasm: Analysis of tumor tissues detected 21 clusters of CD45+ cells, including 7 clusters of CD4+ T cells (CD3+, CD4+; clusters 7, 8, 10, 12, 14, 15, 21), 5 clusters of CD8+ cells (CD3+, CD8+; clusters 13, 16, 17, 19, 20), 2 clusters of B cells (CD19+, CD20+; clusters 1 and 4), 1 cluster of tumor-associated macrophages (CD3-, CD14+, HLA-DR, CD163+, CD206+; cluster 2), 1 cluster of tumor-associated neutrophils (CD3-, CD66b+; cluster 5) and 5 cell clusters that could not be fully classified (clusters 3, 6, 9, 11, 18) (Figure 6A–D).