ACSL1 and esophageal squamous cell carcinoma: In the ESC-410 and KYSE-150 cell lines with a silenced-ACSL1 genome (sh-ACSL1), the exogenous overexpression of OIP5 can restore ACSL1-mRNA expression, demonstrating that OIP5 promoted lipid metabolism at the cellular expression level of the key enzyme ACSL1 to further regulate fatty acid metabolism in ESCC (Figure 6C).