To evaluate the tumorigenic ability of OIP5 in ESCC, the same ESCC cell lines described above were selected and divided into three groups including, the control group (sh-NC), silenced-OIP5 gene group (sh-OIP5), and silenced-OIP5 gene group with an exogenous overexpression of OIP5 gene (sh-OIP5 + OIP5). The gene discussed is OIP5; the disease is esophageal squamous cell carcinoma.