As the SNPs rs1546124, rs8061351, rs2326398 and rs4783099 in CRISPLD2 were previously analyzed in this same case-control sample [13], we sought to verify whether SNP-SNP interactions among variants in CRISPLD2 and genes of its pathway could increase the prediction risk for nonsyndromic orofacial clefts. This evidence concerns the gene CRISPLD2 and orofacial cleft.