To our knowledge, only one study approached multiple autophagy-related genes (ATGs) in a pilot study where it was found that there was a different expression of multiple genes in the autophagy pathway in both early- and late-stage colorectal cancer and where several genes related to apoptosis such as BCL2 and CASP3 were down-regulated [33]. The gene discussed is CASP3; the disease is colorectal cancer.