In this respect, we sought to investigate the role of methylation% of the MEFV gene exon 2 as a biomarker for FMF in the Egyptian population, and whether DNA methylation could be used as a diagnostic and prognostic marker by studying its relation to pyrin level, disease severity, phenotypic picture, MEFV gene mutations, and colchicine response. Here, MEFV is linked to familial Mediterranean fever.