Several studies have addressed FMF disease in the Egyptian population [20,37,38,39,40,41,42,43], but the novel portrayals in our study are detecting the methylation% of the MEFV exon 2 and the pyrin concentration in FMF Egyptian patients, and whether we could target DNA methylation and pyrin level as future diagnostic and prognostic biomarkers by studying their relations with gender, consanguineous marriage, similarly affected family members, phenotype, disease severity, genotype, biomarkers, and drug response. This evidence concerns the gene MEFV and familial Mediterranean fever.