The MEFV exon 2 methylation% in FMF patients harboring different mutations was as follows: R202Q (25.1 ± 20.8), M694V (24.8 ± 9.3), M694I (21.5 ± 11.9), E148Q (20.9 ± 15.7), V726A (18.9 ± 7.9), and M680I (18.9 ± 7.9) (p = 0.448), while the highest pyrin concentration (pg/mL) was detected in FMF patients who carried M694V (416.8 ± 60.9), followed by V726A (399.5 ± 52.1), M680I (395.6 ± 56.7), M694I (387.2 ± 88.8), E148Q (366.9 ± 63.1), and R202Q (322.3 ± 36.8) mutations (p = 0.601). This evidence concerns the gene MEFV and familial Mediterranean fever.