At the protein level the number of MCF-7 cells in which caspase 8 was activated was significantly higher in the sample cultured with CIMVs-TRAIL (8.15 ± 0.9%) (n = 3, **** p < 0.0001) compared to native CIMVs (3.35 ± 0.1%), CIMVs-BFP (3.41 ± 0.1%) and control tumor cells cultured without addition of the vesicles (3.65 ± 0.1%). This evidence concerns the gene CASP8 and neoplasm.