CASP8 and neoplasm: Apoptosis induction in the tumor cells was confirmed at the mRNA level by a 3.5-fold increase (n = 3, **** p < 0.0001) in the CASP8 gene mRNA level in cells treated with CIMVs-TRAIL and a 2.4-fold increase (n = 3, **** p < 0.0001) in cells treated with native CIMVs or CIMVs-BFP compared to control without the addition of CIMVs.