Changes in the expression level of genes involved in the intrinsic pathway of apoptosis in tumor cells after interaction with native CIMVs and CIMVs-BFP can also be mediated by microRNA carried by vesicles since it has been shown that miR-20a-3p from exogeneous MSC-derived vesicles can promote TRAIL-related apoptosis [53]. This evidence concerns the gene RNF112 and neoplasm.