At the same time, the mRNA level of the CASP8 gene was also increased in tumor cell samples that were cultured with native CIMVs (by 2 times) and CIMVs-BFP (by 2.2 times) (n = 3, **** p < 0.0001), but not as significant as in the case of CIMVs-TRAIL. The gene discussed is CASP8; the disease is neoplasm.