The role of VitD in hepatic pathophysiology and its progression has attracted attention after studies have reported the upregulation of VitD receptors (VDR) in injured hepatocytes such as hepatocellular carcinoma and nonalcoholic fatty liver disease (NAFLD) compared with normal hepatocytes [27,28,29,30]. This evidence concerns the gene VDR and metabolic dysfunction-associated steatotic liver disease.