YY1 is overexpressed in NSCLC and co-expressed in the NSCLC gene network [6], probably related with the activation of cell proliferation and invasion [141], forming a regulatory loop with cancer stem cell transcription factors (SOX2, OCT4, and BMI1) in the NF-kB/PI3K /AKT axis [142]. The gene discussed is SOX2; the disease is cancer.