RFX2 and lung cancer: Moreover, most of the transcriptional regulatory network is also important for other types of cancer, with FOXF1, HOXC6, and RFX2 being the only ones that seem to be lung-cancer-specific biomarkers, and even though SOX4 and SOX17 are deregulated in all lung cancer datasets, they are also deregulated in some types of breast cancer and leukemia, suggesting a more general tumor function [12].