EPAS1 and neoplasm: EPAS1 (endothelial PAS domain-containing protein 1 or hypoxia-inducible factor 2 alpha (HIF2α)) is related to vascular network remodeling [117], tumor angiogenesis, tumor size, tissue invasion [118], metastasis, cell dedifferentiation, enhanced glycolytic metabolism, antiapoptotic activity, and genomic instability [119].