NR2F1 or Coup-TF1 (nuclear receptor subfamily 2, group F, member 1) is an orphan nuclear receptor of the retinoic acid receptor family, known as a tumor dormancy marker, which is downregulated in cancer to promote cell proliferation [109] and metastasis by inducing the epithelial–mesenchymal transition [110,111]. This evidence concerns the gene ESRRB and neoplasm.