SOX17 represses and SOX4-enhanced canonical Wnt signaling (Figure 10) to keep up CSC proliferation, self-renewal, and differentiation, thus assisting the invasion and metastasis of lung cancer through the regulation of Wnt target genes mainly related to cell cycle, stem cell pluripotency, and epithelial–mesenchymal transition (Figure 11) [81]. Here, SOX17 is linked to lung cancer.