ZBTB16 (zinc finger and BTB domain-containing 16, promyelocytic leukemia zinc finger protein (PLZF), or zinc finger protein 145 (ZFP145)) is a tumor suppressor gene that is downregulated by promoter hypermethylation, which stimulates cancer cell proliferation, migration, invasion [124], metastasis [125], high tumor grade, tumor stage, and shorter overall survival in NSCLC [126]. This evidence concerns the gene ZBTB16 and cancer.