Hypoxic-stabilized EPAS1 proteins transactivate DNMT1, promoting EPAS1 promoter hypermethylation and thus decreasing EPAS1 mRNA levels, which is much lower in poorly differentiated tumors compared with well and moderately differentiated ones, indicating that it can be a poor prognosis marker of NSCLC [120]. The gene discussed is DNMT1; the disease is non-small cell lung carcinoma.