KLF4 and cancer: CENPF is one of the most frequently dysregulated LC DEGs related to cell division and differentiation, along with seven of the most frequently dysregulated LC-PAH TFs (FOXF1, LMO2, SOX4, ID4, NR2F1, ZBTB16, and MEIS1) (Table S1), and three of the most frequently dysregulated lung cancer TFs (SOX17, DLX5, and KLF4), suggesting a role in the process of cancer stem cells’ differentiation into lung cancer cells (Figure 11).