KEGG pathway analysis revealed that cisplatin caused a change in the expression of genes involved in microRNAs in cancer, retinol metabolism, metabolic pathways in 24 h cisplatin group and metabolic pathways, microRNAs in cancer, PI3K-Akt signaling pathway, transcriptional misregulation in cancer, MAPK signaling pathway, pathways in cancer, axon guidance, proteoglycans in cancer, Rap1 signaling pathway, focal adhesion, p53 signaling pathway, cytokine–cytokine receptor interaction, TNF signaling pathway, endocytosis, FoxO signaling pathway and so on in 48 h cisplatin group (Tables S1 and S2). This evidence concerns the gene AKT1 and cancer.