TNF and neoplasm: Due to the decrease in the proportion of proliferating MNCs (lymphocytes CD3+) in some of the co-cultures with tumor cells plus hBM-MSC-cm, we decided to assess the levels of some cytokines present in the supernatants of the groups studied, because the balance between pro-inflammatory (e.g., TNF) and anti-inflammatory (e.g., IL-4, IL-10, and TGF-β) cytokines is key to controlling the regulation of the immune response [48].