In addition, several cancer-related studies have shown that LSD1 can also demethylase non-histone proteins, such as forkhead box A1 (FOXA1), hypoxia-inducible factor 1-α (HIF-1α), P53, DNA methyltransferase 1 (DNMT1), transcription factor E2F1, and tumor suppressor gene PTEN [29,30]. This evidence concerns the gene KDM1A and cancer.