However, it is undeniable that LSD1 is an important target for regulating the transformation of adipose tissue, and LSD1 can indeed become an important target for the treatment of obesity-related metabolic diseases, providing some new ideas for improving the pathophysiological state related to adipose tissue transformation, such as diabetes and atherosclerosis. Here, KDM1A is linked to obesity due to melanocortin 4 receptor deficiency.