It has been described that Ntn1 is related to the most common microvascular complications of T2D, such as diabetic retinopathy, in which angiogenesis mediated by HIF-1alpha and Vascular Endothelial Growth Factor (VEGF) is increased, as well as inflammation via NF-kB in the retina, thus explaining the pathophysiology of the disease [11,12]. This evidence concerns the gene NTN1 and diabetic retinopathy.