Ntn1 can thus be proposed as a new risk marker for the development of T2D, which would provide a new tool with which we may evaluate patients with T2D and its relationship to the inflammatory status; which, along with vascular damage, is responsible for the microvascular complications associated to T2D, as well as diabetic retinopathy and diabetic nephropathy. This evidence concerns the gene NTN1 and type 2 diabetes mellitus.