People with severe COVID-19 have symptoms of systemic hyperinflammation, mediated by a rapid release of inflammatory molecules, especially inflammatory cytokines such as interleukin (IL)-1β, IL-18, IL-6 and tumor necrosis factor-α, and the protein Gasdermin D (GSDMD) which is a marker of inflammatory cell death.1 The gene discussed is GSDMD; the disease is COVID-19.