SHC1 (S246), TTC7A (S182), CDC42EP3 (S89) and RIPOR1 (S351) were also significantly and stably activated at all the time points screened, suggesting that they may have important roles in the biology of HER2-expressing breast cancer cells (Fig. 2A; Fig. S2B). The gene discussed is CDC42EP3; the disease is breast carcinoma.