SHC1 (S246), TTC7A (S182), CDC42EP3 (S89) and RIPOR1 (S351) were also significantly and stably activated at all the time points screened, suggesting that they may have important roles in the biology of HER2-expressing breast cancer cells (Fig. 2A; Fig. S2B). This evidence concerns the gene ERBB2 and breast carcinoma.