Major specificity regulons were found in high CD161 expression tumor cells, including RORA_extended, MYC, MAFF_ extended, XBP1, MXD4_ extended, KLF8_ extended, and STAT4_ extended, while major regulons in low CD161 tumor cells including EOMES_ extended, IRF8, STAT3_extended, NUAK2_ extended, NFATC1, IRF4_ extended and NFIL3_ extended (Figure 10E). The gene discussed is IRF8; the disease is neoplasm.