A total of 20 key targets were screened out in PPI analysis, and signaling pathways including pathways in cancer, lipid and atherosclerosis, endocrine resistance, human cytomegalovirus infection, hepatitis B, microRNAs in cancer, AGE-RAGE signaling pathway in diabetic complications, HIF-1 signaling pathway, and TNF-α signaling pathway were observed to play an important role in the mechanism of HQHG for ITP treatment. Here, HIF1A is linked to atherosclerosis.