TNF and autoimmune thrombocytopenic purpura: In this study, rutin showed the highest LibDockScores and forms many close interactions including conventional hydrogen bonds, Pi-Sulfur, Pi-alkyl, and carbon hydrogen bond to the residues of EGFR, CASP3, TNF, and STAT3, which indicated that rutin in HQHG plays an important role in the treatment of ITP.