Mechanism studies have shown that F-AgÅPs can activate PDH by inhibiting PDK so that the glucose metabolism state of osteosarcoma cells changes from glycolysis to mitochondrial aerobic oxidation, thereby selectively inducing osteosarcoma cells (rather than normal cells) to generate ROS-mediated apoptosis (Hu et al., 2020). Here, PDP1 is linked to osteosarcoma.