Via IHC assay, Zhang et al. illustrated that ASPN was significantly upregulated in GC, which was related to the poor prognosis of GC patients. The upregulation of ASPN promoted the growth of GC cells and inhibited apoptosis via deactivating LEF1-gene transcription independent of β-catenin in vitro and in vivo. The gene discussed is LEF1; the disease is gastric cancer.