IGFBP1 and gastric adenocarcinoma: Relative mRNA levels of IGFBP1 and CHAF1A in STAD and matched paracancerous tissues were evaluated via qPCR in overall-, early-, and progressive-stage STAD (Figure 9A), and the results showed the expression of IGFBP1 was significantly elevated in early-stage STAD in comparison with matched normal tissues (p = 0.018, Figure 9A-top), which was in line with bioinformatics findings.