Yuya Sato et al. reported IGFBP1 could predict hematogenous metastasis in patients with gastric cancer (Sato et al., 2019), while another research demonstrated that the role of IL35 in GC angiogenesis was altering TIMP1, PAI1, and IGFBP1 (Li X. et al., 2020b). Here, IGFBP1 is linked to gastric cancer.