Interestingly, six mRNAs, including SCGB3A1, SRARP, MUC5B, GABRB1, CNMD, and KRT27, were all up-regulated in early-stage STAD but down-regulated in progressive-stage STAD, while these targets were not significantly different when brought into overall STAD samples (Supplementary Table S4). The gene discussed is CNMD; the disease is gastric adenocarcinoma.