IGFBP1 and gastric cancer: Luo et al. suggested that compared with the control groups, IGFBP1 was significantly upregulated in GC cells infected with H. pylori 26695. However, its overexpression could reduce the promoting effect of MMP-9 on the BGC-823 cells migration, indicating the protective role of IGFBP1 in the process of H. pylori-induced GC