In the previous study of dry eye caused by ocular surface stimulation, inflammation after exposure to proinflammatory cytokines mainly depended on the activation of NF-κB. For example, TNF-α may induce multiple cellular effects through NF-κB signaling pathways such as apoptosis [44], cell death, and production of chemokines [45]. The gene discussed is NFKB1; the disease is Keratoconjunctivitis sicca.