In the Naringin treated group (NAR+VAN) there is a decreased number of NLRP3 positive cell in the SNc and CPu when compared to the Parkinson's induced group (VAN), this just shows that Naringin inhibits the activation of NLRP3 and production of Tumour Necrosis Factor alpha [21]. This evidence concerns the gene NLRP3 and Parkinson disease.