VEGF can cause the late-onset motor neuron degeneration similar to ALS [123]. Spinal cords of ALS patients show reduced expression of VEGF and its receptor [124]. Certain SNPs in the VEGF gene are associated with the lower level of VEGF expression and higher risk of ALS, suggesting a link between VEGF levels and ALS susceptibility [125]. Here, VEGFA is linked to amyotrophic lateral sclerosis.