This aggregate included genes of notable significance to diabetic nephropathy, specifically in the tubulointerstitial compartment for CXCL6[97], [98], and for the key DN target C3, which was recently identified in a bioinformatic analysis [99] and was shown to be involved in complement-system mediated glomerular and tubular injury using the ZS rat model [100]. This evidence concerns the gene CXCL6 and diabetic kidney disease.