Interestingly, however, in a proximal tubular‐specific NOX4 KO mouse model of diabetic kidney disease (DKD), deletion of NOX4 had no beneficial effect on albuminuria, kidney fibrosis or glomerulosclerosis, suggesting that NOX4 localization within the tubular proximal compartment is not essential for DKD progression.50 This evidence concerns the gene NOX4 and diabetic kidney disease.